Abstract

DRESSENDORFER, L M; JERVIS, C  and  PALACIOS, S. Therapeutic efficacy of Goeckerman's method in patients with plaque psoriasis. Rev. argent. dermatol. [online]. 2006, vol.87, n.4, pp.238-246. ISSN 1851-300X.

This is an experimental, prospective, double blind, placebo-controlled, experimental study to demonstrate the effects of coal tar plus UVB treatment (Goeckerman's method) compared with PUVA in patients with psoriasis. The study was performed at the Department of Dermatology of the Hospital Carlos Andrade Marín (HCAM Quito-Ecuador) during August - November 2001. The study considered 99% significance levels and a potency of 90%. The selection of the samples was unintentional and subjects were assigned to the treatment groups using PEPI random assignment package. The sample was consisted in 26 subjects equally assigned to both arms of the study (Goeckeremans vs PUVA). The difference among treatment groups were measured using Krusal Wallis tests using EPI-INFO and EXCEL software. Mean age for each group were 45.3 for PUVA, and 44.1 for Goeckerman (average 44.7). The initial PASI score for both groups was 22.9 (PUVA: 20.27, Goeckerman: 25.69). The group was composed by 5 women and 21 men distributed randomly among treatment arms. The adverse events included pruritus (62.9% PUVA, 100% Goeckerman), erythema (42.2% PUVA, 84.6% Goeckerman). Systemic adverse effects included nausea and dizziness only in PUVA 46.2% and 30.8 respectively. The percentage of PASI score reduction was 51.6%.

Keywords : Psoriasis; Phototherapy; PUVA; Goeckerman.

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