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Revista argentina de dermatología

On-line version ISSN 1851-300X

Abstract

GOMEZ, MT; ARIAS, SC; SANDOVAL, L  and  CELIS, LG. Darier  white disease: Case report and relationship with neuropsychiatric diseases. Rev. argent. dermatol. [online]. 2018, vol.99, n.2, pp.1-10. ISSN 1851-300X.

Darier White or dyskeratosis follicularis disease is a genetic disorder of autosomal dominant trait, affecting chromosome 12q23-24.1. It starts at first or second decade of life, it is characterized by cutaneous manifestations due to several hyperkeratotic papules that affect seborrheic areas such as head, neck and thorax. This article seeks to present reports of cases of two patients in a Hospital in Bogotá-Colombia and their relationship with psychiatric illnesses such as bipolar affective disorder and mental retardation. A complete clinical history was made, the patients were examined, and informed consent was signed for taking pictures and using them for educational purposes. With this information, we proceeded to look for bibliography in the most recognized databases such as: Pubmed, Science Direct, Embase using advanced searches with key words, related words like Darier White disease and its relationship with psychiatric illnesses in general. Finally, each of the cases described as Darier's disease was approached with the clinical association of psychiatric illnesses such as bipolar affective disorder and mental retardation, with which this disease shows a close relationship in relation to the percentages of presentation.

Keywords : Darier's disease; bipolar affective disorder; mental retardation; acantholysis; dyskeratosis.

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