Abstract

CUERVO, Miguel Mateo  and  VELASQUEZ, Margarita María. FOLLOWING THE FOOTSTEPS OF INTERLEUKIN - 23. ITS ROLE IN PSORIASIS. Rev. argent. dermatol. [online]. 2019, vol.100, n.2, pp.1-10. ISSN 1851-300X.

Psoriasis is a multisystem chronic inflammatory disease with skin involvement, worldwide distribution that affects all ages and both sexes; Genetic, immunological and environmental factors interact within its complex etiological origin. It has been described that the relationship of IL-23 and Th17 lymphocytes form an axis that is intimately associated with the pathogenesis of this disease. IL-23 is produced by macrophages and dendritic cells and is composed of two subunits, p40 which is common for IL-12, and p19 that is unique to IL-23. Since p19 is abundant in the skin with psoriasis, molecules have been designed to block it, and to date they have shown clinical efficacy in the control of skin lesions. In this review article we present the general panorama of IL-23 in psoriasis and the advent of molecules aimed at modifying its biological activity.

Keywords : Psoriasis; cytokine; interleukin-23; pathogenesis; immunology.