Abstract

PENA-SANCHEZ, M et al. PORPHYRINS IN A CASE OF PORPHYRIA CUTANEA TARDA: FOLLOW-UP STUDY. Rev. argent. dermatol. [online]. 2019, vol.100, n.3, pp.16-20.  Epub Sep 30, 2019. ISSN 1851-300X.

Porphyrias are rare congenital errors in the metabolism of porphyrins. Porphyria cutanea tarda is the most frequent among different types of porphyrias. We report the follow-up study of porphyrin metabolites of a 51-year-old patient with porphyria cutanea tarda four years later of her diagnosis. During this period, it was indicated a therapeutic scheme of phlebotomies in the Institute of Hematology and Immunology. One of the complementary examinations for its follow-up was the determination of total porphyrins in the urine, plasma and feces. Porphyrins in plasma decreased from 13 500 nmol/L at onset of disease to 250 nmol/L four years later. Although, porphyrins in feces and plasma could not quantify, we observed non-presence of peaks at 405 nm and 615.1 nm, respectively. These results contributed to corroborate the usefulness of the study of these metabolites for monitoring of this disease and effectiveness of the treatment.

Keywords : porphyria cutanea tarda; porphyrins; urine; plasma; feces.