Abstract

WILLINER, ME et al. Clarithromycin-induced toxic epidermal necrolysis with good response to intravenous immunoglobulin, and cyclosporine. Case report. Rev. argent. dermatol. [online]. 2021, vol.102, n.2, pp.31-40. ISSN 1851-300X.

Toxic epidermal necrolysis (NET) is a severe adverse skin reaction that causes generalized necrosis of keratinocytes. It is produced by an inadequate immune activation by drugs or their metabolites.

The drugs that have been most frequently related are: sulfa drugs, pyrazolones, anticonvulsants and allopurinol. The occurrence with clarithromycin is rare.

There are no systemic therapies for NET. Complementary therapies that have been used include: systemic corticosteroids, intravenous immunoglobulin, cyclosporine, plasmapheresis, and anti-TNF monoclonal antibodies.

We present the case of an adult patient with NET secondary to clarithromycin, with a good response to intravenous immunoglobulin, and cyclosporine.

Keywords : Toxic epidermal necrolysis; clarithromycin; cyclosporine; immunoglobulin.

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