Abstract

GAGGINO, MP et al. Atypical presentation of perianal extramammary Paget's disease, treated with topical imiquimod. Rev. argent. dermatol. [online]. 2021, vol.102, n.3, pp.17-20. ISSN 1851-300X.

Perianal extramammary Paget disease is a very low frequency intraepithelial adenocarcinoma of the anal margin. The primary form represents a neoplasm of apocrine origin, while the secondary form represents a pagetoid spread of a generally anorectal malignant neoplasm. Due to its clinical similarity with other pathologies with frequent presentation, a high index of suspicion is required to diagnose it. Wide surgical resection or Mohs micrographic surgery is commonly considered the mainstay of treatment with high recurrence rates. Previous studies have shown a good response in vulvar extramammary Paget disease with imiquimod 5% cream, but its efficacy has not been well described in perianal involvement. In this article we present a case of primary perianal extramammary Paget disease with HPV superinfection, which received topical treatment with imiquimod.

Keywords : Extramammary Paget's disease; perianal Paget's disease; imiquimod; skin cancer; anal neoplasia.

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