Abstract

GIOVAMBATTISTA, A.; CASTROGIOVAMI, D.  and  SPINEDI, E.. Efecto de esteroides sexuales sobre la función endocrina adipocitaria e insulinosensibilidad periféricaEffect of sexual steroids over the adipocyte and outlying insulin sensitivity. Rev. argent. endocrinol. metab. [online]. 2008, vol.45, n.4, pp.149-161. ISSN 1851-3034.

Sex hormones are known to modulate body composition and endocrine functions. The aim of the present study was to analyze the impact of sexual steroids administration on the outlying insulin-sensibility and adipocyte secretory function. Groups of female rats received either vehicle (C), E2 valerate, or T propionate. Daily food intake and body weight were recorded until sacrifice under basal conditions or after high glucose load test. Plasma concentrations of leptin, E2, T, glucose, triglycerides, and insulin (INS) were evaluated. The parametrial adipose tissue was pondered and adipocytes were isolated and then incubated with or without INS. E2 induced early hypophagia (p< 0,05); contrarily, T induced moderate hyperphagia (p<0,05). Weight and fatty parametrial mass values were lower for E2- than C-treated animals (p<0,05). Plasma levels remained unmodified either for E2 or T groups, though E2 animals developed hyperleptinemia (p<0.05). The high glucose load test showed increased and decreased insulin-sensitivity (p<0.05) in E2 and T groups, respectively. Finally, E2 and T isolated adipocytes were less sensitive to insulin-induced leptin secretion than C cells (p<0.05 vs. C). Our study reveals that E2 and T hormones affect sensibility to insulin as well as adipocyte functions.

Keywords : Leptin; Testosterone; Estradiol; Adipocyte; Insulin.

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