Abstract

BONNEAU, GA  and  PEDROZO, WR. Adiponectin, TG/HDL chol index and CRPhs: Predictors of Insulin resistance. Rev. argent. endocrinol. metab. [online]. 2013, vol.50, n.2, pp.78-83. ISSN 1851-3034.

The initial disturbance of insulin resistance appears to focus on adipose tissue which is a dynamic organ involved in many physiological and metabolic processes. Expresses and secretes a variety of active peptides, adipocytokines. The aim of this study was in urban population of the countryside, represented by employees of two public hospitals in the province of Misiones, to determinate the relationship between circulating levels of TG/HDL-c index, adipose tissue metabolism (adiponectin) and inflammatory markers (hsCRP) with insulin resistance metabolism. We evaluated 176 employees of 2 public hospitals in Posadas, Misiones, 117 women and 59 men, aged 49.01 ± 9.33 years. The exclusion criteria were subjects with diabetes, hypothyroidism or hyperthyroidism, infectious disease, renal or hepatic neoplasms and pregnant women. They performed a blood sample with 12 hours of fasting. Blood glucose (cv = 2.43 %) and triglycerides (cv = 2.45 %): were measured by enzymatic colorimetric method according to Trinder. HDL-c (cv = 3.41 %) by homogeneous method. Insulin (cv = 4,2 %) and the high-sensitivity C-reactive protein (hsCRP) (cv = 2,1 %) were determined by a chemiluminescent immunometric assay on a solid phase Immulite 2000-Siemmens. Adiponectin with monoclonal antibodies (ALPCO immunoassays). All samples were processed with calibrators, trade controls normal and pathological and control of internal and external quality. Statistic analysis was made by Epi Info 6.04d, with a 95 % confidence level and a significance level of < 0.05. 17.2 % of sample were IR and 45.7 % had decreased concentrations of adiponectin. We found that IR was associated with the Adiponectin (p < 0.001), hsCRP (p = 0.02) and TG/HDL-c index (p = 0.02). The parameter that best explained the event IR was serum adiponectin concentration. We can conclude that hormone‘s determination may improve a new opportunity current risk estimates.

Keywords : Insulin resistance; Adiponectin; CRPhs; Index TG/HDL chol.

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