Abstract

UNGER, G; BENOZZI, SF; PERRUZZA, F  and  PENNACCHIOTTI, GL. Cardiovascular Risk in Patients with Overweight or Obesity and Mild Decrease in Glomerular Filtration Rate. Rev. argent. endocrinol. metab. [online]. 2013, vol.50, n.3. ISSN 1851-3034.

The occidental world has suffered an alarming increase in the prevalence of obesity, which is associated with the development of cardiovascular disease (CVD) and chronic kidney disease (CKD). It has been demonstrated that obesity induces pathophysiologic disturbances that promote renal injury, and at the same time, renal dysfunction has been associated with the onset of cardiovascular events and mortality. The aim of this study was to evaluate if a mild impairment in renal function is associated with an increased cardiovascular risk (CVR) in subjects with overweight or obesity. From a total of 454 individuals who presented at the Preventive Medicine Department of Hospital Municipal de Bahía Blanca, 205 (45 %) adults of both genders with over-weight or obesity and with no other cardiovascular risk factor were enrolled. Clinical and biochemical data were obtained from these individuals. Glomerular Filtration Rate (GFR) was estimated with the abbreviated equation Modification of Diet in Renal Dis-ease, CVR was determined with Reynolds score. Nineteen percent of the studied population had a mild impairment in glomerular filtration (GF), GFR between 60 and 89 mL/min/1.73m², with normal creatinine values, with a higher proportion of patients with increased CVR (23 %) being found in this group as compared to the group with no GF impairment (14 %), p=0.153. A significant association was found between mild impairment of GF and age older than 50 years (p = 0.000). In this study, we concluded that it is necessary to optimize CKD screening in overweight or obese individuals by incorporating the estimation of GFR in routine practice and performing a complete renal function evaluation including urinary albumin measurement and other imaging studies, to determine whether they should be classified or not into stage 2 of CKD with the aim of preventing CKD and CVD. No financial conflicts of interest exist.

Keywords : Cardiovascular risk; Chronic kidney disease; Obesity.

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