Abstract

BERTINI, K et al. Osteoimmunology: An Integrated Vision of Immune and Bone Systems. Novel Perspectives for Bone Diseases. Rev. argent. endocrinol. metab. [online]. 2013, vol.50, n.4, pp.241-252. ISSN 1851-3034.

Osteoimmunology is a research field that deals with the study of the interaction between the immune system and bone tissue. Enough evidence demonstrates that they share regulatory mechanisms. This interaction occurs through direct contact between the cells of both systems and by the action of immune regulatory mediators, cytokines and growth factors. The aim of this review is to provide an overview of the interaction between bone and immune cells and the role they play in the mutual development and function. A greater knowledge of the interaction of these two systems will allow a better understanding of the role of immunology in the pathogenesis of bone mass loss.

Keywords : Bone; Immune system; Interaction; Cytokines; Transcription factor.

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