Abstract

INSUA, A  and  GARCIA, L. Long-Term Follow Up of Thyrotropinomas: The Role of Radiotherapy and Long-Acting Somatostatin Analogs. Report of Two Cases. Rev. argent. endocrinol. metab. [online]. 2015, vol.52, n.3, pp.120-128. ISSN 1851-3034.

Thyrotropinomas or TSHomas are functioning pituitary adenomas that produce central hyperthyroidism and are often detected at macroadenoma stage, with the expected mass effects of large pituitary tumors. We report the long-term outcome of two thyrotropinomas, and discuss the treatment options adopted and available for these patients. Our first patient was seen 4 years after diagnosis of hyperthyroidism and two years after pituitary surgery, with persistent disease. The second subject was diagnosed soon after the detection of a symptomatic pituitary mass with extrasellar extension, with the corresponding clinical and laboratory workup. None of them was cured by surgery alone; both were treated with somatostatin analogs and radiotherapy with a clear improvement of their condition.

Keywords : Thyrotropinomas; Long-term evolution; Radiotherapy; octeotride.

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