Abstract

ELORMENDI, C et al. Clinical Utility of Bone Remodeling Markers Taking Into Account the Reference Value Change. Rev. argent. endocrinol. metab. [online]. 2015, vol.52, n.4, pp.198-203. ISSN 1851-3034.

The Modeling and Remodeling processes are conducted through the process of replacement bone at specific sites called Units Bone Remodeling (URO).These can be evaluated by biochemical markers of formation and resorption that reflect changes in skeletal metabolism. These markers of bone turnover are used for research óseo-metabolic diseases because they provide dynamic information of bone metabolism and can be quantified in serum or urine. The variation of these markers is mainly due to preanalytical, analytical and biological variables and should be interpreted taking into account the Reference Value Change (VRC), which results from a calculation in which the biological variability (VB) of the analyte and the random error of the method used in the laboratory are involved.

Keywords : Bone markers; Delta check; Formation markers; Resorption markers; Metabolic bone diseases.

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