Abstract

BIELSKI, Laila Y; ORLANDI, Ana M  and  BOQUETE, Hugo R. Tyrosine kinase inhibitors and thyroid dysfunction. Rev. argent. endocrinol. metab. [online]. 2016, vol.53, n.3, pp.96-105. ISSN 1851-3034.

Tyrosine kinase inhibitors are used for the treatment of different types of tumours, interfering in various cell proliferation pathways, and tumour angiogenesis. These oral agents have side effects, thyroid dysfunction outstanding among them. There are different mechanisms through which these agents lead to hypothyroidism, as well as thyrotoxicosis. There is still no consensus on the treatment and follow-up of the above mentioned effects.

Keywords : Tyrosine kinase; Tyrosine kinase inhibitors; Renal cell carcinoma; Gastrointestinal stromal tumours.

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