Abstract

TORRESANI, María Elena. Vitamin D status in controlled hypothyroid adult women: Relationship with nutritional status. Rev. argent. endocrinol. metab. [online]. 2016, vol.53, n.4, pp.128-134. ISSN 1851-3034.

Introduction: Vitamin D deficiency is prevalent worldwide. It can affect people of different ages. This vitamin deficiency has been linked with diseases such as type 2 diabetes mellitus, insulin resistance, metabolic syndrome, obesity, cardiovascular disease, cancer, immune disorders, muscle disorders and falls, among others. Objective: To determine the plasma concentrations of vitamin D in hypothyroid adult women and its relationship with nutritional status. Material and methods: A retrospective cross-sectional study limited to 80 hypothyroid adult women, aged over 40 years, controlled with levothyroxine, and for whom weight, height, and 25-hydroxyvitamin D (25OHD) data were available. They attended a private clinic in Martínez (Buenos Aires Province, Argentina). Dependent variable: Serum 25(OH)D concentration (ng/ml) stratified as sufficient (> 30 ng/ml), mild deficiency (20 to 30 ng/ml), and severe deficiency (<20 ng/ml). Independent variable: nutritional status by BMI, classified as normal weight (18.5 to 24.9 kg/m²) and overweight or obesity (≥ 25 kg/m²). Data were obtained from clinical records. Total serum 25(OH)D concentration was measured using radioimmunoassay (Diasorin^NR) in a fasting venous blood specimen by the laboratory of the medical centre. Weight and height were measured by a nutritionist using standardised methodology. Statistical analysis was performed using SPSS 19.0 software, establishing measurements of central tendency. Mean differences were compared using the Student t-test or ANOVA, X², and Pearson correlation, with significance level set at P<.05. Results: The mean age was 57.4 (SD: 5) years, with 57.5% being of normal weight and 42.5% overweight or obesity. The mean value of 25(OH)D was 26.9 (SD: 10.5) ng/ml. Sufficient vitamin status, was observed in 35%, a mild deficiency in 36.3%, and a severe deficiency in 28.7%. No significant differences were found between the mean 25(OH)D and thyrotropin (TSH) levels (P=.563). There was a significant inverse association between 25(OH)D and BMI (r = -0.577; P=.000) and age (r = -0.270; P=.015). Conclusions: Most of the patient sample showed decreased plasma levels of 25(OH)D. Serum 25(OH)D was shown to decrease as body weight and age increased.

Keywords : Vitamin D; Hypovitaminosis; Hypothyroidism; Nutritional status; Adult women.

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