Abstract

SCHMIDT, Angelica; CROSS, Graciela  and  PITOIA, Fabián. Distant metastases in differentiated thyroid carcinoma: Diagnosis and treatment. Rev. argent. endocrinol. metab. [online]. 2017, vol.54, n.2, pp.92-100. ISSN 1851-3034.

Distant metastases occur in less than 10% of patients with differentiated thyroid carcinoma. In these patients, overall survival at 10 years is considerably reduced. Whereas cure is the initial goal of treatment, stabilisation of the disease and management of symptoms have become the primary objective in many patients with persistent radio-iodine refractory progressive disease. In the last decade, several targeted therapies have shown encouraging results in patients with advanced disease. The objective of this review is to describe the characteristics, diagnosis, overall survival, and the local and systemic available treatments for patients with distant metastases from differentiated thyroid cancer.

Keywords : Thyroid cancer; Tyrosine kinase inhibitors; Refractory; Radio-iodine; Distant metastases.

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