Abstract

MUNIZ-ALIQUE, M. DIEZ  and  FERNANDEZ, E. LÓPEZ. Recidiva tardía de insulinoma. Asociación con otras patologías. Rev. argent. endocrinol. metab. [online]. 2019, vol.56, n.3, pp.41-50. ISSN 1851-3034.

Insulinoma is a pancreatic neuroendocrine tumor characterized by the production of insulin and represents 10 to 30% of pancreatic tumors in individuals with MEN 1. The metastases are rare. We present a recurrent pancreatic neuroendocrine tumor producing insulin after several years of the first surgery. The presence of other lesions suggests the possibility of a MEN1 syndrome; even the genetic study was negative. This fact does not rule out that the patient suffers from the syndrome since up to 5-25% ofthe reported cases with MEN1 syndrome may not have mutations. Management of these tumors may be complex Everolimus is a treatment option in these patients.

Keywords : insulinoma; hypoglycemia.

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