Abstract

RAMIREZ, Y, TALAVERA; ARES, RM,; PEDROZO, WR,  and  BONNEAU, GA,. Evaluación del déficit de vitamina d en mujeres adultas. Rev. argent. endocrinol. metab. [online]. 2019, vol.56, n.4, pp.21-30. ISSN 1851-3034.

in adult women who attend the Tajy Clinic in Encarnación, Republic of Paraguay. To determine the prevalence of hypovitaminosis and the relationship that exists with phosphocalcic metabolism, as well as to evaluate the association of cardiovascular risk factors to hypovitaminosis D in this population of women.

120 women were studied, 61 pre-menopausal and 59 in post-menopause. With median and 25 and 75 percentiles for age 48 (35-62), who attended the Tajy Laboratory in Encamación Paraguay from January 2015 to March 2016. Blood samples were taken and a survey was carried out in order to collect information on those covariates that may influence the variables of interest and where all have signed a consent. Pregnant women, women with diabetes, with hypertension, nephropathies, neoplastic diseases, thyroid diseases, inflammatory or infectious processes, who are under treatment or supplement of any kind were excluded. We obtained data on weight, height, waist circumference and blood pressure. A blood extraction with fasting of 12 hours was performed for biochemical determinations. All samples were processed with internal and external quality control.

It was found that 72% of these women had hypovitaminosis D (< 30 ng/ml) , where 38% were pre-menopausal, highlighting that within this population the highest percentage of women with severe vitamin D deficiency was found and 39% were post-menopausal. A statistically significant difference was found (p <0.001) with age, systolic blood pressure, waist circumference, glycemia, HDL-cholesterol concentration, triglyceride concentration and TG / HDL-col index, as well as calcium and phosphorus (p <0.001). It was found that the concentration of vitamin D had a significant correlation with the measurement of waist circumference, calcium and phosphorus concentration (p <0.001). It was found that 67 women with abdominal obesity had low vitamin D levels (<20 ng / ml), those with abdominal obesity had 15 times more risk of hypovitaminosis D than those with a waist circumference of <88 cm.

Through this research, and analyzing the behavior of vitamin D concentration in pre and post menopausal women, we found that 72% of them presented hypovitaminosis D, in which 38% were pre-menopausal women and 39% were menopausal This hypovitaminosis D has a significant correlation with calcium and phosphorus concentrations, as well as with other variables such as age, systolic blood pressure, glycemia and HDL cholesterol concentration. Vitamin D deficiency has a significant association with abdominal obesity in this population of women.

Keywords : Vitamin D.

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