Abstract

GIACOIA, EG,; COSTANZO, PR,  and  MANSUR, JL,. Variación estacional de los niveles de vitamina D y su relación con la obesidad en una población de embarazadas de alto riesgo en Buenos Aires. Rev. argent. endocrinol. metab. [online]. 2019, vol.56, n.4, pp.31-40. ISSN 1851-3034.

Obesity is a risk factor for vitamin D deficiency and both determine to maternal-fetal pathologies. In our country there is a wide seasonal variation ofvitamin D levels.

Aim: To evaluate the relationship between vitamin D levels, season and body mass index (BMI) in high-risk pregnant.

Method: Cross-sectional study, patients were evaluated in the third trimester of pregnancy. It was considered: age, week of pregnancy, BMI, season and 25OHD measurement Obesity was defined: BMI >30 kg/m2. Vitamin d status was classified as: severe deficiency: <10 ng/ml, deficiency: 10.1-19.9 ng/ml, insufficiency: 20-29.9 ng/ml and sufficiency >30 ng/ml.

Results: 60 pregnant of 30.1±6.3 years, in third trimester (31.2±4.3 weeks) were included. 25OHD values were lower in winter (n=19) vs summer (n=41): 10.7±3.5 vs 26.3±8.2 ng/ml (p<0.0001). According 25OHD in winter vs summer, patients with severe deficiency: 47.4% vs 2.5% (p<0.0001), deficiency: 94.7% vs 17.1% (p<0.0001), insufficiency: 100% vs 61% (p=0.001). No patients had levels of sufficiency in winter vs 39% in summer. Obese patients (n=22) had lower levels of 25OHD vs non-obese (n=38): 18.0±9.1 vs 23.4±10.3 ng/ml (p=0.04). According to BMI and season, obese had lower 25OHD compared with non-obese in winter: 8.9±1.4 vs 11.8±3.9 ng/ml (p=0.03), and summer: 22.2±7.9 vs 28.7±7.6 ng/ml (p=0.01)

Conclusions: High-risk pregnant in the third trimester have significantly lower vitamin D in winter than in summer and in obese than in non-obese. Patients with obesity in winter should be considered high risk ofvitamin D deficiency.

Keywords : High-risk pregnant; Vitamin D Obesity Winter.

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