Abstract

COALOVA, Isis; MENCACCI, Santiago  and  FASSIANO, Anabella V. Pesticide mixtures genotoxicity: More than the sum of its parts?. Acta toxicol. argent. [online]. 2013, vol.21, n.1, pp.5-14. ISSN 1851-3743.

A crucial factor of the Green Revolution has been the development and application of pesticides to prevent the potential harm of a variety of organisms that affect crop yields of agronomic interest. However, the sustained increase in the use of these compounds resulted in an enhancement of their presence in the environment, affecting ecosystems and human health. Populations are exposed to complex pesticide mixtures because they are usually combined and commercial formulations content several additives. Considering the scientifc output on the subject in recent years, the aim of this work is to evaluate advancement on the genotoxicity of pesticides and their mixtures at similar concentrations to those found in the environment. Moreover, given the complexity of monitoring studies and the lack of certainty to establish direct correlations, it is proposed to recognize the applicability of short-term tests of minor complexity as an approximation to the real context.

Keywords : Genotoxicity; Mixtures; Pesticides; Monitoring.

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