Abstract

PALERMO, Ana María  and  MUDRY, Marta Dolores. Ethanol and isopropanol: genotoxicity and teratogenicity evaluated using Drosophila melanogaster as a model system. Acta toxicol. argent. [online]. 2014, vol.22, n.3, pp.122-135. ISSN 1851-3743.

Ethanol and isopropanol are two of the short chain aliphatic alcohols more frequently associated to the human environment, both in the industrial and domestic conditions. The aim of this work was to present the main findings reported in the literature about their genotoxicity and teratogenicity in experimental models of different level of complexity, with special emphasis in Drosophila melanogaster. Taking into account that the metabolism of both alcohols in Drosophila and humans is similar, the fly is a good model for the evaluation of their potentially toxic, genotoxic and teratogenic effects.

Keywords : Ethanol; Isopropanol; Genotoxicity; Teratogenicity.