Abstract

ZACHARZEWSKI, Carolina L et al. Obesity and insulin resistance as risk factors in breast cancer. Rev. cienc. tecnol. [online]. 2016, n.26, pp.47-52. ISSN 1851-7587.

The aim of this paper is to evaluate how Obesity and Insulin Resistance affect the development of breast cancer in menopausal and no menopausal women. A total of 101 patients were studied; 49 women with breast cancer, and 52 controls matched by age. Glucose and insulin levels, HOMA and BMI (body mass index) were determined. The 67% of cancer patients was at menopausal stage and the remaining 33% in premenopausal or reproductive stage. The cancer patients had a higher HOMA value (median = 2,26, IR=1,29-4,46) than non-cancer patients (median = 1,76, IR= 1,37-2,43) with p-value 0,018. Among women with cancer, 36,7% were normal-weight, 42,9% were overweight and only 20,4% were obese, observing significant differences with regard to the control sample, and a higher BMI in premenopausal women. The HOMA increase, would raise breast cancer risk by a 33%.

Keywords : Breast Cancer; Obesity; Insulin Resistance; HOMA; BMI.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )