Abstract

LOPEZ, Miryan S et al. Evaluation of the need for biopsy in a pediatric population with suspected Celiac clinical disease. Rev. cienc. tecnol. [online]. 2017, n.28, pp.64-70. ISSN 1851-7587.

The aim was to evaluate the diagnosis value of serological tests in a pediatric population with suspected celiac disease. In the serum of patients with classical symptoms, non-classical symptoms, or with an increased risk for celiac disease, antibodies anti-tissue transglutaminase IgA (a-tTG-IgA) and IgG anti-deamidated gliadin peptide (a-DGP-IgG) were measured. Endoscopic biopsy was performed on 97 patients: 62 of them had Marsh 3 lesion (celiac disease confirmed), 7 had Marsh 2 lesion and the other 28, Marsh 0-1 lesion. A 100% of positive predictive value for a tTG-IgA ≥ 100 U ml, and 95% for a-DGP-IgG ≥ 100 U/ml were obtained. When both (tTG-IgA and a-DGP-IgG) were ≤ 10 U/ml, the negative predictive value was 100%. Values of a-tTG-IgA ≥ 100 U/ml allowed the diagnosis of celiac disease in the studied population. When a-tTG-IgA and a-DGP-IgG, were both ≤ 10 U/ml it ruled out celiac disease.

Keywords : Celiac disease; Tissue transglutaminasa; Antibodies; Deamidated gliadin peptide; Biopsy.

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