Abstract

CUENYA, Lucas; SERAFINI, Matías; MUSTACA, Alba E.  and  KAMENETZKY, Giselle. Efecto del haloperidol sobre el contraste sucesivo positivo consumatorio en ratas adultas con aislamiento adolescente. Rev Arg Cs Comp. [online]. 2015, vol.7, n.2, pp.00-00. ISSN 1852-4206.

Abstract. Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation. Rats exposed to adolescent isolation (AA) show neurological and behavioral disorders into adulthood, many of them related to changes in response to appetitive reinforcers. Previous studies showed an increase of consummatory Successive Positive Contrast (cSPC, i.e., increased consumption of 32% sugar solution, 24 hours after having access to 4% solution) in rats exposed to AA, in comparison to animals without AA. This study aim at evaluating whether this effect is associated with dopaminergic hyperactivity. Haloperidol (0.1 mg / kg, i.p.) was administered before animals with AA were exposed to the presentation of the increased solution (4% to 32%), while saline was administered to the control group. cSPC effect was not observed in animals receiving haloperidol, while a one trial positive contrast was expressed in animals receiving saline. These results confirm the proposed hypothesis. Although the results are promising, further experiments are needed to determine more precisely the neurochemical correlate of increased cSPC in animals with AA.

Keywords : Adolescent Isolation; Positive Contrast; Haloperidol; Dopamine; Rat.

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