Abstract

JIMENEZ, Juan C; CORTES-SALAZAR, Felipe; CEDILLO-ILDEFONSO, Benita  and  MIRANDA, Florencio. La administración sistémica e intra-accumbens del agonista 5-HT1B CP94253 modula la auto-administración oral de etanol en ratas. Rev Arg Cs Comp. [online]. 2022, vol.14, n.1, pp.68-81. ISSN 1852-4206.

It has been suggested that some addictive properties of ethanol (EtOH) are modulated by 5-HT1B receptors in the nucleus accumbens (nAcc). This research was designed to assess the effects of systemic and intra-accumbal administration of the 5-HT1B receptor agonist CP94253 on the oral self-administration of EtOH in rats. Male Wistar rats were water deprived for 24 h, and then trained to lever-press for EtOH reinforcement on a FR3 schedule until response rate remained stable at 80%. After this training, a group of rats received an intraperitoneal injection of 5-HT1B receptor agonist CP94253 before rats were under FR3 schedule of reinforcement for EtOH access. Another group of rats, after similar training, received intra-accumbal injection of CP94253. The data showed that both systemic and intra-accumbal injections reduced oral self-administration of EtOH. These findings suggest that the 5-HT1B receptors activation may modulate the reduction of oral self-administration of EtOH in rats.

Keywords : 5-HT1B receptors; EtOH; nAcc; self-administration.

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