Abstract

BASTIDAS-LEGARDA, Leidy Y et al. Description of an in vivo oral mucosa HSV-1 infection model in miceDescripción de un modelo murino de infección por HSV-1 a través de la mucosa oral. Acta odontol. latinoam. [online]. 2017, vol.30, n.3, pp.109-112. ISSN 1852-4834.

In this work, we established an in vivo murine model of herpes simplex virus type 1 (HSV-1) infection involving inoculation by scarification of the oral mucosain order to study its dissemination towards the trigeminal ganglion (TG). Both viral DNA and infectious virions were detected on the third day postinfection (p.i.). Viral proteins revealed by immunohistochemistry were mainly found at seven days p.i., when the latency-associated transcript (LAT) was also detected. This model simulated the dissemination process of HSV-1, which could be used to study herpes pathogenesis starting in the oral mucosa.

Keywords : Herpes Simplex Virus 1; Mouth Mucosa; Trigeminal Ganglion; Latency associated transcript.

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