Abstract

MARTINEZ, Cristian; OLMEDO, Daniel  and  OZOLS, Andres. Matriz para ingenieria de tejido oseo: modificacion superficial con zinc Estudio preliminar. Rev. Asoc. Argent. Ortop. Traumatol. [online]. 2013, vol.78, n.3, pp.138-143. ISSN 1852-7434.

The aim of this study is to develop a method of matrix synthesis for tissue engineering, capable of accelerating reparative processes and reducing the risk of infection, destined to reconstructive surgeries involving bone tissue. For this purpose the bovine bone mineral phase, hydroxyapatite, was used while retaining its dimensional structure. This is obtained from a chemical wash process followed by a thermal process that removes the entire organic components. This matrix is superficially modified with zinc oxide (ZnO), element known for its action in various biological processes and its antibacterial action. The procedure involves the intrusion of ZnO dispersions in alcohol solution-1,2,3-propanetriol, made in a thermal bath and the subsequent high temperature sintering. The degree of attachment and the Zn concentration on the hydroxyapatite matrix is determined by electron microscopy and energy spectrometry. X-ray diffraction shows that the incorporation of Zn ions in the surface forms Zn phosphates. The developed original process allows modifying in a simple way synthetic bone grafts, by providing antibacterial and osteoproliferative properties to the osteoconductive substrate.

Keywords : Tissue engineering; Hydroxyapatite; Scaffolds; Zinc.

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