Abstract

MOLINA ROMOLI, Agustín R et al. El uso de plasma rico en plaquetas para desgarros musculares agudos: revisión sistemática y metanálisis de la evidencia actual. Rev. Asoc. Argent. Ortop. Traumatol. [online]. 2020, vol.85, n.1, pp.82-90. ISSN 1852-7434.

Introduction: Acute muscle tear is the most common type of injury in sports activities. There is a present interest in the search of modalities that could shorten and improve healing time. The use of platelet-rich plasma (PRP) has increased over the past years, but such popularity does not count with sufficient scientific support to back up its effectiveness. The purpose of this study is to collect, analyze and summarize the available published data so as to clarify the effects of PRP use on muscle tears through a systematic review and meta-analysis. Materials and Methods: We conducted a systematic review of the literature on the use of PRP for the treatment of acute muscle injuries. A meta-analysis was conducted to evaluate the effects of PRP. Results: A total of 7 papers met the inclusion criteria for analysis: six randomized controlled trials and one cohort study. The overall time to return to sports after PRP treatment was a mean of 29 days (range, 10 to 50.9 days), and in the control groups was a mean of 35.4 days (range, 22 to 52.8 days). The meta-analysis (5 of the 7 papers) showed a significant difference in earlier return to sports with the use of PRP when compared to conventional therapy (-7.80 days; P=0.007). No difference in the recurrence rate was reported. Conclusions: The meta-analysis demonstrated a favorable effect of PRP when compared to conventional therapy. However, our analysis demonstrated significant study heterogeneity. Thus, our findings should be interpreted with caution. We still cannot recommend the use of PRP for the treatment of muscle tears.

Keywords : Platelet-rich plasma; Growth factors; Muscle injuries; Muscle tear; Regenerative medicine; Biologics.

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