Abstract

KOZIMA, S. et al. Biopsia prostética randomizada: ¿influye el número de muestras y el valor del PSA para la detección del cáncer prostético?. Rev. argent. radiol. [online]. 2016, vol.80, n.1, pp.7-15. ISSN 1852-9992.

Objective: To determine whether obtaining a larger number of core specimens, depending on the PSA value, increases the detection of prostate cancer. Materials and methods: A cross-sectional study was conducted on 994 patients with suspected prostate cancer who underwent transrectal ultrasound-guided prostate biopsy. The patients weredivided intogroup Awith a standard protocol (8 core specimens or more scheme) and group B with an extended protocol (12 core specimens or more scheme), and subdivided according to the PSA values into three groups (<3.9ng/ml, 4 to 9.9ng/ml, and > 10ng/ml). The prostate cancer detection rate was evaluated in each subgroup. Clinical data was analysed using the Student t and chisquared tests and logistic regression analysis, taking a P< 0.05 as statistically significant. Results: The detection rate of prostate cancer in the group A was higher than group B: 43.71% vs. 34.29%; P = 0.022. When analysing the results, taking into account the sub-division of PSA results, no significant statistical differences were found in the detection of malignancy in the two groups of patients evaluated. Conclusión: Increasing the number of core specimens in transrectal ultrasound-guided prostate biopsy, does not increase the overall detection rate of prostate cancer in either of the PSA sub-groups, or in either of the of prostate volume sub-groups. On the other hand, the older the patient and the higher the PSA value, the greater the detection of prostate cancer.

Keywords : Prostatic neoplasms; Prostate-specific antigen; Biopsy; Diagnosis.