Abstract

GONZALEZ AGUILAR, Osvaldo et al. Melanomas no cutáneos de cabeza y cuello: Enfermedad de pronóstico sombrío. Rev. argent. cir. [online]. 2013, vol.104, n.2. ISSN 2250-639X.

Background: Non cutaneous are 1-7% of all melanoma. The prognosis is poor in spite of which, technological progress may change the outcome. Objective: To discover factors which allow to define progress of last 20 years. Design: Retrospective, observational. Setting: Public Hospital of tertiary care. Population: 30/56 male patients with 1.15/1 rate. Mean age 61.07 years old. Priority sites in mucosal melanoma were palate with 22-39.2% and paranasal sinus with 9 (16%). Ocular melanomas were 42.8% of the sample. 94.6% were EI. Methods: Extention of surgery was simple resection in 13/56 (23.2%), ocular enucleation in 14/56 (25%), orbit exenteration in 5/56 (9%) maxilectomy in 20/56 (35.7%), craniofacial resection in 3 and nasal amputation in 1. Results: Morbility was 51.7% and mortality 1.7%. 67.8% of the sample recurred. Multivariate analysis for recurrence showed that rinosinusal and conjuntival sites unfavorably influence on that event. At close of observation 42/56 (75%) was dead, 85.8% of them for specific cause. Only 2 death happened after 60 months. Five years specific survival was 31.9%. Palate and stage I were favorable sites with statistic significance. Conclusions: Other paradigms of treatment are urgently necessary for this disease which outcome was not substantially modified in the last 20 years.

Keywords : Non cutaneous melanoma; Mucosal melanoma; Survival of melanoma.

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