Abstract

MUSSANO, Eduardo et al. Cutaneous T cell lymphoma in a patient with rheumatoid arthritis. Rev. argent. reumatolg. [online]. 2016, vol.27, n.4, pp.52-55. ISSN 0327-4411.

Patients with RA are at increased risk for several disorders, including cancer, infection and cardiovascular diseases. Rates of hematological malignancies (i.e. lymphomas, myeloid leukaemia) are elevated in this patient population. This is a case of a 74 years old male patient with longstanding nodular and polyarticular RA, treated with etanercept and abatacept without efficacy, later rituximab 2 g/ yr for 3 years, with very good response. Maintenance treatment: tofacitinib 5 mg/d orally. In april 2016, he presented nodular and erytemathous lesions in legs, necrotizing ulcers in left leg, bullous lesions in feet and edema in lower limbs to thigh. Treatment stops. Skin biopsy: T cell cutaneous lymphoma with dermal and hypodermic commitment. First chemotherapy cycle (CHOP) well tolerated but after second CHOP cycle the patient presented bone marrow aplasia and died

Keywords : rheumatoid arthritis; T cell cutaneous lymphoma.