Abstract

RODRIGUEZ, María Florencia; TROITINO, Cristian; ROMANINI, Felix Enrique  and  SECCO, Anastasia. Minor salivary gland biopsy: its importance in rheumatoid arthritis and secondary Sjögren's syndrome. Rev. argent. reumatolg. [online]. 2019, vol.30, n.3, pp.15-18. ISSN 0327-4411.

Secondary Sjögren's Syndrome (SSs) is common in patients with Rheumatoid Arthritis (RA). Objectives: To determine if lymphocytic sialoadenifitis (FLS) is associated with clinical and serological differences in a group of patients with RA and SSs. Methods: Patients with a diagnosis of RA and SSs were included, which of them presented FLS in the salivary gland biopsy, clinical and serological characteristics were compared. Results: 88 patients were included, 92% women, mean age of 53 years (SD ± 11.3) and 12.5 years of evolution of RA (RIC 6-7). 63.6% had SLF versus 36.4% who did not. In the univariate analysis, a statistically significant association was found between FLS + and the variables: parotidomegaly, interstitial lung disease, hypergammaglobulinemia, hypocomplementemia, rheumatoid factor, positive ANF, and extra-articular and/or extraglandular manifestations. In the multivariate analysis, the variables independently associated with the presence of FLS were: extra-articular and/or extraglandular manifestations (OR 5.67, 95% CI 1.6-20), positive ANF (OR 11.7, 95% CI 1.6-83) and hypergammaglobulinemia (OR 21, 95% CI 2.46-179). Conclusion: Patients with RA and SSs with FLS have a higher frequency of extra-articular and extraglandular manifestations and serological differences, which would imply a different clinical follow-up.

Keywords : secondary Sjögren's Syndrome; rheumatoid arthritis; minor salivary gland biopsy; lymphocyte sialoadenitis.

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