Abstract

BENZAQUEN, Nadia; RIERA, Julia; GIMENEZ, Sebastián  and  CASTRO, Maximiliano. Acute secondary adrenal insufficiency due to spontaneous adrenal hemorrhage in antiphospholipid syndrome: a case series. Rev. argent. reumatolg. [online]. 2023, vol.34, n.4, pp.131-134. ISSN 0327-4411.  http://dx.doi.org/10.47196/rar.v34i4.789.

In adrenal insufficiency (AI), the progressive destruction of adrenal tissue leads to a decrease in the secretion of adrenal corticoids, such that once established, the clinical picture becomes severe, and without treatment, there is a high mortality rate. Antiphospholipid syndrome (APS) is a rare cause of AI. Given this and the scarcity of available literature, two cases of AI due to APS are presented in a private clinic in the city of Santa Fe, Argentina.

Both cases were characterized by being female, having a previous diagnosis of APS, and not having other sites of thrombosis at the time of consultation. The manifestation as adrenal hemorrhage and the fact of being previously on anticoagulant therapy posed a diagnostic challenge.

Although AI is an uncommon condition, and even more so when linked to APS, the severity of the pathology, as well as the rapidity of its onset, warrant a high clinical suspicion when the syndromic picture is suggestive.

Keywords : Addison disease; corticoadrenal insufficiency; antiphospholipidic syndrome.

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