Abstract

BONO, Julio O.; LIBERMAN, Federico  and  RICARTE BRATTI, Juan P.. Interactions in antithrombotic and hypoglycemic therapy. Medicina (B. Aires) [online]. 2022, vol.82, n.6, pp.934-942. ISSN 0025-7680.

This review is an update on antiplatelet therapy and its interaction with oral hypoglycemic agents in diabetic patients with ischemic heart disease. We summarize the main pathophysiological mechanisms that intervene in diabetic patients and that increase the ischemic risk, the effects of the combination of oral hypoglycemic agents, their antithrombotic ef fects and their interaction with antiplatelet, and finally the studies that demonstrated the benefits of antiplatelet in diabetic patients in different scenarios of ischemic heart disease. The different mechanisms of action involve improved glycemic control, increased bioavailability of nitric oxide, reduced oxidative stress and, for certain mol ecules, direct inhibition of platelet activation and aggregation.

Keywords : Antiplatelet agents; Coronary artery disease; Antidiabetic drugs; Hypoglycemic drugs.

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