Abstract

MANGANO, Andrea María Mercedes. Genetic factors in hiv-1 infection. Acta bioquím. clín. latinoam. [online]. 2007, vol.41, n.4, pp.467-481. ISSN 0325-2957.

In the last decade numerous findings have helped to unveil the complex viral-host interactions determining HIV-1 pathogenesis. Viral entry is the first step in the establishment of HIV infection. In this phase, the virus needs to interact with two cellular receptors, the CD4 molecule and a chemokine receptor (mainly CCR5 or CXCR4). Viral envelope features determine the usage of cellular coreceptors thus, virus that use CCR5 or CXCR4 are named R5 and X4, respectively. Viral-coreceptor interactions could be blocked, at least partially, by the CCL3, CCL4 and CCL5 chemokines. Several studies have shown that genetic variations in the chemokines and their receptors may affect HIV-1 transmission and disease progression. In this article the influence of host genetic and viral factors is reviewed as well as our experience in Argentina.

Keywords : Human immunodeficiency virus; Coreceptor; Chemokine; Host genetic factors; Pathogenesis; Pediatric immunodeficiency syndrome.

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