Abstract

URIOSTE, Alejandra. Actualización en marcadores inmunológicos en el estudio de la infección por HIV: aportes desde el laboratorio clínico. Acta bioquím. clín. latinoam. [online]. 2023, vol.57, n.2, pp.191-201. ISSN 0325-2957.

Although a correct adherence rate to antiretroviral treatment in human immunodeficiency virus (HIV) infection reveals a substantial clinical improvement in people living with HIV, achieving access to treatment is still challenging. Laboratory studies for diagnosis and follow-up are mainly focused on virological status, CD4+ and CD8+ T cells counts. However, the immunological profile of people living with HIV is not evaluated in detail, neither is the immune reconstitution after treatment. Consequently, the aim of this review was is to describe, on the one hand, the studies carried out in the laboratory for the diagnosis and monitoring of HIV infection, and on the other hand, is to describe the contributions of the biochemical laboratory in the study of the immunological profile of people living with HIV. This study includes determinations currently in use, and the determination of new soluble or cell membrane inflammatory biomarkers, as well as T cell subsets. These biomarkers could be valuable tools as descriptors of the impervious state of people, and even predictors of pathologies associated with HIV infection.

Keywords : HIV; Biomarkers; Immune reconstitution; Immunological profile; T-cells subsets.

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