Servicios Personalizados
Revista
Articulo
Indicadores
Citado por SciELO
Links relacionados
Similares en SciELO
Compartir
Medicina (Buenos Aires)
versión impresa ISSN 0025-7680versión On-line ISSN 1669-9106
Resumen
KAUFFMAN, Marcelo A. et al. Is tumor necrosis factor - 376a promoter polymorphism associated with susceptibility to multiple sclerosis?. Medicina (B. Aires) [online]. 2007, vol.67, n.5, pp.436-438. ISSN 0025-7680.
A single nucleotide polymorphism (SNP) at position -376 of the tumor necrosis factor á gene (TNFA) has been associated with susceptibility to multiple sclerosis (MS) in Spain. However, no association was found in populations from the USA and The Netherlands. Here we investigate the association between the TNFA - 376A SNP and MS susceptibility in Argentinean patients with MS. The A/G genotype was found in 4.4% of patients (n=90) and in 4.8% of healthy individuals (n=84; p=0.92; odds ratio=0.93; confidence interval: 0.23- 3.84). Thus, no significant differences in genotype and allele frequencies were found between healthy individuals and patients with MS in Argentina.
Palabras clave : Genetic risk; Multiple sclerosis; Single nucleotide polymorphism; Tumour necrosis factor.