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Acta bioquímica clínica latinoamericana
versión impresa ISSN 0325-2957versión On-line ISSN 1851-6114
Resumen
Metabolic liver diseases. Acta bioquím. clín. latinoam. [online]. 2016, vol.50, n.4, pp.583-608. ISSN 0325-2957.
Human liver, an extraordinary organ with multiple vital functions, takes up a privileged anatomic position, whose strategic site enables it to receive information from the rest of the organism. It is possible to observe liver disease with probable systemic complications, or extrahepatic manifestations that can affect the liver.They could be overthrow metabolisms because of some substances with a direct impact on the gland leading to different liver diseases. Such is the case of Alpha 1 antitrypsin deficiency (a glycoprotein deficiency) which leads to neonatal colestasis and cirrhosis in young and adults, and potentially develop hepatocellular carcinoma. Copper and ironmetabolisms and their accumulation load the hepatocites as a result give rise to Wilson disease and hemochromatosis, respectively. These metabolic diseases, of less frequency in Argentina, are hard to be diagnosed world wide and can lead to premature death. This short revision is aimed at emphasizing that metabolic diseases are not rare and can mimicry different liver diseases.
Palabras clave : Liver; Alpha-1 antitrypsin; Copper; Iron.