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Revista argentina de microbiología
versión impresa ISSN 0325-7541versión On-line ISSN 1851-7617
Resumen
CRUZ CHOAPPA, Rodrigo et al. Virulence of Sporothrix globosa in murine models. Rev. argent. microbiol. [online]. 2016, vol.48, n.3, pp.196-199. ISSN 0325-7541. http://dx.doi.org/10.1016/j.ram.2016.04.007.
Introduction: The sporothricosis disease is an infection caused by species included in Sporothrix schenkii complex. Objective: Verify the virulence of a strain of S. globosa using two different concentrations of inoculum by intraperitoneally and subcutaneously, into a mouse model. Materials and methods: Nonrandomized pilot study, in murine inoculated with a strain of S. globosa (CBS 14.076 M) by intraperitoneally and subcutaneously with inoculum concentrations of 0.5 and 4 McFarland. For this purpose 18 rodents CF-1 (ISP, Santiago, Chile) were used. Results: The studied strain did not induce illness or injury on animals, they all survived and neither the tissue culture nor the histopathological analysis showed fungal growth or suggestive infection by organ abnormalities. Conclusions: The S. globosa strain did not present any virulence enough to cause disease at 0.5 and 4.0 McFarland concentration inoculum when inoculated in both intraperitoneally and subcutaneously, in murine models.
Palabras clave : Sporotrichosis; Sporothrix globosa; Pathogenicity.