Resumen

GONZALEZ GOMEZ, Carlos Alfonso; DE LA TORRE, María Laura  y  PISONI, Cecilia Nora. Autoimmune seronegative encephalitis associated to primary Sjögren’s disease. Rev. argent. reumatolg. [online]. 2023, vol.34, n.3, pp.99-104. ISSN 0327-4411.  http://dx.doi.org/10.47196/rar.v34i3.774.

Autoimmune encephalitis is an immune-mediated disorder that affects different areas of the brain parenchyma, often involving deep gray matter or the cortex, with or without involvement of white matter, meninges, or spinal cord. It is frequently associated with autoimmune or paraneoplastic diseases and is a diagnostic challenge. We report the case of a 55-year-old woman with history of Sjögren's syndrome who presented to the emergency department with headache and episodes of confusion. Cerebrospinal fluid (CSF) analysis showed leukocytosis with neutrophilia. Brain MRI revealed multiple restricted diffusion lesions with hyperintense signal on T2 and FLAIR sequences, predominantly in the bilateral occipital region, right cerebellar hemisphere, and right parietal region. Infections and neoplasms were ruled out. The panel of antibodies for autoimmune encephalitis, including Aquaporin-4 and anti-MOG in CSF, was negative. She received intravenous methylprednisolone, leading to symptom improvement.

Palabras clave : autoimmune encephalitis; primary Sjögren syndrome; central nervous system.

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