Resumen

MITELMAN¹, Jorge E.  y  GIMENEZ², Luisa. De la miocardiopatía chagásica a la miocardiopatía isquémica no aterosclerótica: Lesión endotelial: alteraciones de la microcirculación en la enfermedad de Chagas-Mazza. Insuf. card. [online]. 2017, vol.12, n.3, pp.97-105. ISSN 1852-3862.

Several studies would show that patients with chronic chagasic pathology have abnormalities in microvascular and epicardial coronary vasomotion due to vascular endothelial dysfunction. Once the endothelial alteration is provoked, the platelet reactivity and endothelial-platelet-cell interaction would increase, resulting in modifications in structural proteins, biochemical disturbances in signal transduction with changes in cell proliferation and function, and inflammatory responses. Once the lesion in the microcirculation was established, ischemia would produce myocytolysis, replacing the cardiac tissue with fibrosis. The clinical importance of these findings is the relationship with the symptoms of angina reported by patients and their contribution to the progression to chronic chagasic cardiomyopathy of patients who have this abnormality of vasomotion in the chronic period without demonstrated pathology.

Palabras clave : Chagas' disease; Endothelial lesion; Score of clinical outcome; New therapies.

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