Resumen

RIOS TREVISAN, Ana et al. Inmunoensayo quimioluminiscente para sífilis en donantes de sangre: ¿Los valores de lectura se correlacionan con el estado de la infección?. Acta bioquím. clín. latinoam. [online]. 2023, vol.57, n.4, pp.4-4. ISSN 0325-2957.

The objective of this work was to compare the performance of treponemal and non-treponemal screening in two periods close in time in blood donors and to analyse the association of the signal strength (signal-to-cutoff, S/ CO) of the chemiluminescent immunoassay (CIA) with the reactivity of the enzymeimmunoassay (EIA) and the rapid plasma reagin (RPR). Donors were screened with treponemal tests. The distribution of the S/CO values obtained by CIA was analysed based on EIA and RPR, and its association was evaluated. Group 1: ELISA+/RPR+ donors and Group 2: ELISA+/RPR-. A total of 76,794 voluntary donations were processed. Comparing the means between groups, it was found that the CIA S/CO ratio was significantly higher for Group 1 donors (19.5 vs. 8.10; p<0.001). In conclusion, the signal strength of the qualitative CIA test would be associated with the reactivity of the RPR and would be related to the course of the infection.

Palabras clave : Syphilis; Treponemal tests; Screening; Blood banks; Signal strength; Reverse algorithm.

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