Resumo

SECULINI PATINO, Carina E; PASCUALINI, María Florencia  e  TABARES, Aldo H. Tratamiento exitoso con fondaparinux en trombocitopenia inducida por heparina y trombosis. Medicina (B. Aires) [online]. 2015, vol.75, n.5, pp.307-310. ISSN 0025-7680.

Heparin induced thrombocytopenia (HIT) is an immune-mediated adverse reaction characterized by thrombocytopenia and paradoxical arterial or venous thrombosis, due to the formation IgG antibodies directed to a multimolecular complex of heparin-platelet factor 4 (PF4). Fondaparinux is a selective factor Xa inhibitor with little affinity for PF4 and thus less likely to induce an immune response, making fondaparinux a potentially useful drug for the treatment of HIT. Herein we report the case of a 73 years old woman with HIT associated with arterial and venous thrombosis that was successfully treated with fondaparinux, with normalization of the platelet countand without progression of thrombosis.

Palavras-chave : Heparin induced thrombocytopenia; Fondaparinux; Thrombosis; Anti PF4 antibodies.

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