Resumo

GONZALEZ-CALLE, Verónica  e  FONSECA, Rafael. Retos y avances hacia la medicina de precisión en el mieloma múltiple. Medicina (B. Aires) [online]. 2017, vol.77, n.3, pp.222-226. ISSN 0025-7680.

In the last few years, next-generation sequencing studies have provided insights into the mutational landscape of multiple myeloma. The identification of actionable mutations might give a precious opportunity for exploring new targeted therapies. Thus, the implementation of promising precision medicine strategies seems to be closer than ever. Throughout this review we describe the main challenges that should to be dealt with in this new era, in order to achieve the main goal of precision medicine, namely matching patients with their right drug. In addition, we provide a review of the most significant preclinical and clinical studies supporting the implementation of precision medicine nowadays. Finally, we highlight the need of clinical trials to evaluate the security and efficacy of these targeted therapies, as well as to validate predictive biomarkers that may allow an appropriate best-candidate selection and improvement of myeloma patients' survival and quality of life.

Palavras-chave : Personalized medicine; Multiple myeloma; Driver mutation; Targeted therapy.

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