Resumo

CATALDO, Federico S. et al. EBER + extranodal NK/T lymphoma in patient with idiopathic CD4 lymphocytopenia. Medicina (B. Aires) [online]. 2021, vol.81, n.3, pp.458-461. ISSN 0025-7680.

Idiopathic CD4 lymphocytopenia (ICL) not related to HIV is an infrequent and severe condition with no etiology defined until now. The concomitant presence of an underlying disease, especially an oncohematological process, could be related to the immune physiopathology and the development of the im munosuppressive state. On the other hand, Epstein Barr virus is a well-known oncogenic pathogen described in the development of several types of lymphoma which might be reactivated in the ICL. There is still no specific treatment for this syndrome, so the therapeutic scope for these patients is the treatment of opportunistic diseases and the administration of specific antimicrobials as prophylaxis. We present a patient with an uncommon asso ciation of an ICL and an extranodal T/NK lymphoma with detection of VEB nuclear RNA by in situ hybridization (EBER). Diagnosis was challenging which led the health team to carry out many studies over several months

Palavras-chave : T-lymphocytopenia; Idiopathic CD4-positive T-lymphocytopenia; Epstein-Barr virus infections; Lymphoma; Extranodal T-NK-cell.

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