Resumo

ROBERTI, María Paula. Lymphagiogenesis in melanomas. Acta bioquím. clín. latinoam. [online]. 2009, vol.43, n.3, pp.339-344. ISSN 0325-2957.

Melanoma skin cancer represents the most deadly of all skin cancers and its high incidence of mortality is due to metastasis. Through the local lymphatic system, the sites of initial metastasis are usually the regional lymph nodes. Despite the clinical relevance of metastasis spreading to lymph nodes is clearly established, not much is known about its molecular mechanisms. The finding of new markers in lymph node cells has made it possible over the last years to start clarifying many questions and controversies related to the interaction between tumour cells and lymph vessels. This chapter deals with the growing information nowadays available to understand lymphagiogenesis in cancer, especially melanoma, its potential application to metastasis diagnosis, disease prognosis and therapeutic strategies.

Palavras-chave : Melanome; Lymphagiogenesis; Metastasis diagnosis.

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