Resumo

CASTRO OCAMPO, Gerardo et al. Cut offs levels of 17-hydroxyprogesterone in screening of Congenital Adrenal Hyperplasia. Acta bioquím. clín. latinoam. [online]. 2014, vol.48, n.2, pp.223-228. ISSN 0325-2957.

The present work studies the usefulness of determining adjusted cut-offs for the quantification of 17-hydroxyprogesterone in dried blood samples on filter paper, taking into account the gestational age and weight of the neonates. The results of 6266 determinations made within the framework of the National Program of Strengthening Early Detection of Congenital Disease were analysed. Data were divided into groups, Group 1: early established from the calculation of the 99 percentiles of the frequency distribution. New cutoff points were: 217.72 nmol/L, 102.14 nmol/L, 61.62 nmol/L and 82.38 nmol/L for groups 1, 2, 3 and 4 respectively. It showed a total rate of 1% false positives with the new cut-off points, which was significantly lower than the rate of 6.2% obtained using the manufacturer's cutoff. This revealed that the use of properly established cut-offs for the study of population reduces significantly the complications derived fromn analysis repetitions and eventually the recitation rate, which is an important contribution to Public Health.

Palavras-chave : Congenital adrenal hyperplasia; 17-hydroxyprogesterone; Screening program; Cut-offs.

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