Resumo

MAGNARELLI, Gladis. Environmental exposure to pesticides: biomarkers in matrices of the mother-placenta-fetus triad. Acta bioquím. clín. latinoam. [online]. 2015, vol.49, n.1, pp.39-53. ISSN 0325-2957.

Biomonitoring plays a key role in the assessment of environmental health of populations exposed to pollutants. This paper analyzes information regarding biomarkers of exposure and biomarkers of susceptibility as well as biomarkers of effect that may be useful in diagnostic and preventive strategies in the exposure to persistent pesticides (organochlorine) and moderately persistent pesticides (organophosphates) in a period of high vulnerability as pregnancy. It also reviews different studies where correlation between biomarkers of exposure in matrices of the mother-placenta-feto triad and the impact on the course of pregnancy and fetal growth as well as the functionality of the brain in childhood has been observed. Finally, this work describes nonspecific novel biomarkers including epigenetic biomarkers, biomarkers of oxidative stress, endocrine disruption and gene expression.

Palavras-chave : Pesticides; Pregnancy; Exposure biomarkers; Effect biomarkers; Biomarkers of susceptibility; Nonspecific biomarkers.

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