Resumo

CORTES, Adrian  e  CORAL, Jonathan. The use of planar electromagnetic fields to explain coupling between HLA-II molecules and peptides. Acta bioquím. clín. latinoam. [online]. 2015, vol.49, n.2, pp.221-228. ISSN 0325-2957.

Following the recent discovery of planar electromagnetic fields in protein systems, this work proposes a mechanism to explain the action of HLA-II molecules in selecting, attracting and coupling with peptide-antigens prior to their presentation to T-helper cells. The mechanism explains such couplings for the first time without recourse to the molecular "key-lock" paradigm. Using these electromagnetic field patterns, eight peptides were designed that showed better coupling capacity with HLA-II molecules than the native CLIP peptide. The novel methodology enables the design of vaccinepeptides with high binding capacity. The discovered electromagnetic patterns further offer an explanation of the universal coupling capacity of CLIP and give rise to a number of solutions and new concepts in molecular immunology.

Palavras-chave : Human leucocyte antigen class II; Class II - associated invariant chain peptide; Vaccine design; Antigen presentation; Key-lock mechanism; Electromagnetic fields.

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