Resumo

CORTES, Adrián; CORAL, Jonathan; BENITEZ, Ricardo  e  MCLACHLAN, Colin. Use of planar electromagnetic fields to explain transduction in T-cell receptors. Acta bioquím. clín. latinoam. [online]. 2016, vol.50, n.4, pp.657-664. ISSN 0325-2957.

The coupling of a ligand with a receptor induces a signal that travels through the receptor until it reaches the intracellular domain, where it triggers a response cascade. By analyzing the coupling of receptor cells (TCR) with foreign antigens, the authors identified the presence of molecular patterns, planar in geometry, within this receptor, that are capable of internalizing the signal produced by TCR/antigen coupling. This mechanism, also found in a range of receptor-ligand systems with greatly differing biological functions, including calcium pump-ADP, gp120-CD4 viral coupling, and the hemoglobin-oxygen system, is quantum in nature and capable of explaining the means of signal transduction in all kinds of biochemical receptors. As such, the finding may facilitate the design of vaccine-peptides with high immunogenicity, as well as make it possible to develop new drugs.

Palavras-chave : Receptor-ligand system; Molecular coupling; Signal transduction; Electromagnetic fields; Coherence; Quantum entanglement.

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