Resumo

DI FILIPPO IRIARTE, Giselle; ORJUELA VARGAS, Julie Liliana; OSORIO ZAMBRANO, William Frend  e  JIMENEZ CAMARGO, Laura Carolina. Detection of Human Papillomavirus E6/E7 mRNA in cervical cancer. Acta bioquím. clín. latinoam. [online]. 2018, vol.52, n.3, pp.361-372. ISSN 0325-2957.

The sexually transmitted infection by the Human Papillomavirus (HPV) is one of the most common in the world. Human papillomaviruses are classified as low risk and high risk. Low-risk HPVs are the cause of benign lesions such as genital warts and condylomata acuminata, while high-risk HPV types can cause malignant transformation of cervical epithelial cells by the action of oncoproteins E6 and E7, which could result in the development of cervical cancer. The detection of levels of HPV E6 and E7 mRNA (messenger RNA) in cervical epithelial cells is being evaluated as a predictive marker of cervical cancer as an alternative to HPV DNA detection techniques. In this article, a critical review was made about the relationship between the detection of E6 and E7 mRNA expression of human papillomavirus and cervical cancer. Furthermore, the techniques currently approved by the Food and Drug Administration (FDA) for the detection of mRNA from the HPV E6 and E7 oncoproteins and the state of the art of HPV in Colombia were reviewed.

Palavras-chave : Papillomavirus; Oncoproteins; Cervical cancer; Cervical cytology.

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